Common Drugs & Their Antidotes
Drug | Antidote |
Acetaminophen/Tylenol/Paracetamol | acetylcysteine (Mucomyst) |
Anticholinergics, diphenhydramine, dimenhydrinate | Physostigmine |
Anticholinesterase | atrophine sulfate or pralidoxime |
Antifreeze | Fomepizole, Ethanol |
Arsenic, Copper, Lead, Mercury | D-Penicillamine (Cuprimine ) |
Benzodiazepines | flumazenil |
Beta-Blocking agents, Calcium channel blockers, Hypoglycemia, Hypoglycemic agents | Glucagon, Epinephrine |
Calcium Channel Blockers | Calcium Chloride, Glucagon |
Coumadin/Warfarin | Phytonadione or Vitamin K |
Cyanide | Amyl nitrite, sodium nitrite, sodium thiosulfate |
Cyclophosphamide | Mesna |
Digoxin | Digibind or Digoxin Immune Fab |
Dopamine | phentolamie (Regitine) |
Ethylene glycol | fomepizole |
ethyllene poisoning | antizol |
Extrapyramidal symptoms (EPS) | diphenhydramine (Benadryl) |
Fluorouracil | leucoverin calcium |
Heparin | protamine sulfate |
Heroin | Naloxone (Narcan) or Nalmefene |
Insulin reaction | glucose (Dextrose 50%) |
Iron | Deferoxamine |
Isoniazid, ethylene glycol | Pyridoxine HCl (Vitamin B6) |
Lead | dimercapol, edetate calcium, disodium, |
Local anesthetics and possibly other cardiac toxins (e.g., bupropion, calcium channel blockers, cocaine, beta blockers, tricyclic antidepressants) | Fat emulsion (Intralipid , Liposyn II , Liposyn III ) |
lovenox | protamine sulfate |
magnesium sulfate | calcium gluconate |
magnesium sulfate | calcium gluconate |
Methanol | Folic acid |
Methotrexate | Leucovorin calcium |
Narcotics, morphine sulfate | naloxone (Narcan) |
Neuromuscular blockade (paralytics) | anticholinesterase agents |
Opioid analgesics | nalmefene or naloxone |
Potassium | albuterol inhaler, insulin & glucose, NaHCO3, kayexalate |
Sodium channel blockers (e.g. cyclic antidepressants), salicylates | Sodium Bicarbonate |
Sulfonylureas | Octreotide (Sandostatin ) |
Tricyclic antidepressants | phyostigmine or NaHCO3 |
Valproic acid | L-Carnitine |